Pharmacogenetics of KCNQ channel activation in 2 potassium channelopathy mouse models of epilepsy
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چکیده
منابع مشابه
Structural Insight into KCNQ (Kv7) Channel Assembly and Channelopathy
Kv7.x (KCNQ) voltage-gated potassium channels form the cardiac and auditory I(Ks) current and the neuronal M-current. The five Kv7 subtypes have distinct assembly preferences encoded by a C-terminal cytoplasmic assembly domain, the A-domain Tail. Here, we present the high-resolution structure of the Kv7.4 A-domain Tail together with biochemical experiments that show that the domain is a self-as...
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Ion channelopathy is a proven cause of inherited human epilepsy, and may play a role in acquired epileptic syndromes as well. Of the many ion channel causes of epilepsy, the h-channel is a potential new addition. H-channels are voltage-gated ion channels with unique biophysical properties. The h-channel exerts a significant modulatory influence on neuronal excitability, and is a target of antie...
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BACKGROUND KCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important physiological functions. Recent reports indicate that KCNQ channels may also be expressed in portal vein where they are suggested to influence spontaneous contractile activity. The biophysical properties of K+ currents mediated by KCNQ channels resemble a current underlying th...
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Channelopathies are inherited genetic changes in ion channel genes that generate a disease. Given the pivotal role of voltage-dependent potassium channels in moderating neuronal excitability, it is not surprising that these channels are well represented among the channelopathies contributing to epilepsy. Voltage-dependent potassium channels are regarded as the “initial responders” that shape an...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2017
ISSN: 0013-9580
DOI: 10.1111/epi.13978